Understanding Infection-Induced Thrombosis: Lessons Learned From Animal Models

نویسندگان
چکیده

برای دانلود باید عضویت طلایی داشته باشید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Interferons as biomarkers and effectors: lessons learned from animal models.

Interferons (IFNs) comprise type I, II and III families with multiple subtypes. Via transcription of IFN-stimulated genes (ISGs), IFNs can exert multiple biological effects on the cell. In infectious and chronic inflammatory diseases, the IFNs and their ISG sets can be potentially utilized as biomarkers of disease outcome. Animal models allow investigations into disease pathogenesis and gene kn...

متن کامل

Food Addiction and Binge Eating: Lessons Learned from Animal Models

The feeding process is required for basic life, influenced by environment cues and tightly regulated according to demands of the internal milieu by regulatory brain circuits. Although eating behaviour cannot be considered "addictive" under normal circumstances, people can become "addicted" to this behaviour, similarly to how some people are addicted to drugs. The symptoms, cravings and causes o...

متن کامل

Lessons From Genetically Engineered Animal Models III. Lessons learned from gastrin gene deletion in mice

Hinkle, Karen L., and Linda C. Samuelson. Lessons From Genetically Engineered Animal Models. III. Lessons learned from gastrin gene deletion in mice. Am. J. Physiol. 277 (Gastrointest. Liver Physiol. 40): G500–G505, 1999.— Gastrin is the principal hormonal inducer of gastric acid secretion. Chronic hypergastrinemia, leading to hypersecretion of gastric acid and increased proliferation of pariet...

متن کامل

Nonalcoholic Steatohepatitis: Lessons from Different Diet-induced Animal Models

and may progress to NASH (nonalcoholic steatohepatitis), cirrhosis and hepatocellular carcinoma [1]. Although NAFLD and NASH are associated together, the pathogenesis of NASH is not yet completely elucidated. The pathogenesis of NASH was considered as the “first hit”, characterized by the accumulation of intrahepatic lipid due to disrupting metabolic pathways and increase vulnerability to cell ...

متن کامل

Understanding the limits of animal models as predictors of human biology: lessons learned from the sbv IMPROVER Species Translation Challenge

MOTIVATION Inferring how humans respond to external cues such as drugs, chemicals, viruses or hormones is an essential question in biomedicine. Very often, however, this question cannot be addressed because it is not possible to perform experiments in humans. A reasonable alternative consists of generating responses in animal models and 'translating' those results to humans. The limitations of ...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

ژورنال

عنوان ژورنال: Frontiers in Immunology

سال: 2019

ISSN: 1664-3224

DOI: 10.3389/fimmu.2019.02569